Abstract #T518

# T518
Effect of supplementation with propylene glycol and lactation period on energy metabolism of lactating ewes.
Simone Pedro da Silva*1, Gilberto de Lima Macedo Junior2, Rogério Pereira dos Santos3, Jhone Talisson Lira de Sousa3, Marina Elizabeth Barbosa de Andrade4, Érica Beatriz Schultz2, Luciano Fernandes de Sousa3, Adriano Santana Crozara2, Nhayandra Christina Dias e Silva4, 1Instituto Federal Goiano, Hidrolândia, Goias, Brazil, 2Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil, 3Universidade Federal do Tocantins, Araguaína, Tocantins, Brazil, 4Universidade Estadual Paulista, Jaboticabal, São Paulo, Brazil.

The objective of this study was to evaluate the effect of supplementation with propylene glycol (PG) in water and the lactation period on energy metabolism of 19 lactating ewes Santa Ines with initial body weight (BW) 58.67 ± 0.80 kg, from calving to weaning (0–90 d), organized into 4 treatments (0.0, 1.5, 3.0 and 4.5% PG) in a completely randomized in a split plot design. The experiment was conducted at sheep sector in Federal University of Uberlândia, Minas Gerais, Brazil. The animals were fed a total mixed ration consisting relation roughage concentrate 67:32. Blood samples were collected every 7 d, totaling 12 blood collections. In these samples we evaluated triglycerides, cholesterol, very low density lipoprotein (VLDL), high density lipoprotein (HDL), low density lipoprotein (LDL), LDL/HDL, β-hydroxybutyrate and enzyme gamma glutamyl transferase (GGT). The supplementation with propylene glycol not affected the levels serum of triglycerides, VLDL, LDL, and LDL/HDL in the blood (P > 0.05). The triglycerides and VLDL levels in the blood showed a linear decrease with the advancing lactation (P < 0.01). The cholesterol and HDL levels in the blood showed quadratic response with maximum cholesterol concentration at 61, 70, 68 e 53 d of lactation and maximum HDL concentration at 58, 86, 58 e 85 d of lactation according with supplementation of 0.0, 1.5, 3.0 and 4.5% propylene glycol, respectively. The β-hydroxybutyrate level showed a linear decrease with the increase of propylene glycol (P < 0.05). There was no effect of lactation period on the levels serum β hydroxybutyrate on the blood (P > 0.05). The level of enzyme gamma glutamyl transferase (GGT) in the blood was not affected by the inclusion of propylene glycol (P > 0.05), but was affected by lactation period (P < 0.01). With 36 d of lactation, sheep showed the maximum concentration of GGT (80.36 IU/L). Supplementation with propylene glycol improved the energy status of the sheep and, thus, caused a reduction in the levels of ketone bodies. We concluded that supplementation with propylene glycol reduces the adverse effects of negative energetic balance in sheep during the lactation.

Key Words: energetic balance, metabolic profile