The objective of the study was to estimate the genetic and phenotypic performance of the herd when voluntary culling of heifers was based on estimated breeding value (EBV) of milk (1st criteria) or Net Merit (NM$) (2nd criteria). A daily dynamic stochastic model that simulates 5000 milking dairy cows, heifers and embryos over time and which included multitrait genetics was used. Heifers were inseminated with conventional (CS) or sexed semen (SS). Surplus dairy cows were culled based on the same criteria used to rank heifers. Genetic and economic changes were measured by the changes in true breeding values (TBV) of milk and NM$, as well as actual phenotypic milk production and profit in a decade. Each of 5 experiment was run 5 times. In the first set of experiments, only CS was used with criteria 1 and 2. The increases in mean ± SE of TBV of milk in first parity cows were 1,243 ± 9 and 1,223 ± 12 kg for criteria 1 and 2 respectively. The corresponding increases in annual milk yield/milking cow were 1,628 ± 31 and 1,607 ± 41 kg. The increases in mean ± SE of TBV of NM$ in first parity cows were $925 ± 10 and $951 ± 6 for criteria 1 and 2, respectively. The corresponding increases in profit/milking cow/yr were $752 and $763. In the second set of 3 experiments SS was used in the first 2 inseminations in heifers with culling of the lowest 20%, 30% and 40% heifers ranked on EBV for DPR. The increases in mean ± SE of TBV of milk in first parity cows were 1090 ± 11, 1084 ± 15 and 1060 ± 4 kg for the 3 heifer cull rates respectively. The corresponding increases in annual milk yield were 1245 ± 44, 1197 ± 42 and 1087 ± 30 kg. The increases in mean ± SE of TBV of NM$ in first parity cows were $975 ± 6, $980 ± 3 and $974 ± 6 for the 3 heifer cull rates respectively. The corresponding increases in profit/milking cow were $680, $685 and $618. In conclusion, the results showed that genetic trends and profitability depended on the genetic culling and reproductive strategies. Future studies will determine optimal combinations of genetic selection and reproductive strategies.