This study was performed to determine whether vulvar administration HCG, either intramuscular (IM) or submucous (SM), influence the reproductive response of goats during the natural anestrous season in Northern Mexico. Anovulatory Alpine goats (n = 30) under intensive conditions were divided in 3 homogeneous groups (n = 10, each) based on body weight (BW; 37.36 ± 8.48 kg) and body condition (BC, 1.96 ± 0.32). On June 29th, 20 mg of progesterone was applied to all of the goats; 24-h later (d 0), 7.5 mg of PGF_2α IM was also applied. Group 1; (GC) received 0.5 ml of isotonic saline solution IM, group 2 (GIM) received 100 UI of hCG of IM and group 3 (GSM) received 100 UI of HCG SM. Estrous activity was registered twice per day from d-0 to d-5 using a male; females accepting mating were considered to be in estrus. Ovulation activity was assessed on d-10 by detecting the presence of at least one corpus luteum while gestation was determined on d-45 both throughout a transrectal ultrasonographic scanning (7.5 MHz). The percentages of females in estrous, ovulating and pregnant were compared with chi². While the control group did not depict any response in either variable, treated groups depicted an important reproductive response without differences (P > 0.05) between treated groups regarding estrus behavior (GIM 100% vs GSM 100%), ovulatory activity (GIM 70% vs GSM 100%), and pregnancy rate (GIM 70% vs GSM 100%). To conclude, regardless of the administration route of 100 IU of HCG, either i.m. or s.m., both treatments were equally efficient to induce sexual activity with significant reproductive outcomes in Alpine goats during the natural anestrous season in northern Mexico (25°N).