Economic efficiency and productivity of 6 farms on cattle production systems were evaluated in Mato Grosso State, Amazon biome, during January 2013 and December 2014, part of the Livestock Low Carbon Integrated Project-ICV. Production and economic data were collected using control software (Prodap Profissional GP) and analyzed by electronic spreadsheets (Microsoft Excel). The systems was developed exclusively on a grazing system with a base herd comprised of Zebu (Nelore) and crossbred Bos taurus × Bos indicus cattle in 4 farms. The total of pasture was 6,560 ha (ha) and 14,260 cattle. The average of pasture was 547 ha/farm and 1,188 cattle/farm. Introduction of technologies related to good practices agricultural of fertilization of pasture, feeding supplementation, breeding program, animal health practices, associated with technical-administrative management were evaluated. The zootechnical and economic indexes were compared by Duncan and Tukey test with significance level of P < 0.05. There was no statistical difference (P > 0.05) between zootechnical indexes, stocking rates was 2.17 animals/ha, 755 kg live weight/ha, 256.73 kg body weight produced/ha and 0.87% of mortality rate. There was no statistical difference (P > 0.05) between economic indexes, total operating costs was US$0.68/kg, net margin of US$165.09/ha. The net present values (NPV) and internal rate of return (IRR) were higher in 2014 than 2013 (P < 0.05), due to increased financial resources for the technologies in 2013. NPV was US$74.92 and US$208.68/ha in 2013 and 2014, respectively (P < 0.05), IRR was 1.43 and 3.49% per month in 2013 and 2014, respectively (P < 0.05). The economic results indicated that the activity of beef cattle in Amazon biome can be sustainable use good agricultural practices.