The effect of different methionine intakes and pig’s individual response to this amino acid in precision feeding program is not completely known. The aim of this study was especially to evaluate the existence of methionine (met) toxicity in traditional group-phase-feeding program and in precision feeding program in which pigs are fed individually with daily tailored diets. Sixty pigs with initial BW of 25 kg (MSE = ± 2.23) were used in a 28-d trial, and were arranged in a 2 × 3 factorial randomized design testing: (1) 2 feeding programs (individual daily program (IDP) or a conventional 1 phase program by group (1PP) and (2) 3 methionine levels (70, 100, or 130% of recommended level). In the IDP pigs had the daily and individually SID lysine requirements (SIDLys) estimated using the Precision Feed model (Hauschild et al., 2012) and in the 1PP the phase SIDLys was established using the average pig of the population at day one (Rostagno et al., 2011). In both programs the amino acids profile was kept constant with exception of met. Blood samples were collected weekly at jugular vena after an 8-h fasting period and analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (CK), plasmatic total protein (PTP), and protein C-reactive (CRP) levels. The variables were analyzed as a 2 × 3 factorial arrangement (confidence interval = 95%) using GLM procedure of SAS. The main effects included feeding program, methionine level, and their interaction (P × L). The met intake inside the IDP was 2.7, 3.7 and 6.0 g/day for the 70, 100 and 130% treatments, in the same order for the 1PP, the met intake was 4.6, 6.1 and 8.5 g/day. The PTP showed no differences among the treatments. The ALT and AST presented quadratic tendency for P × L interaction (P < 0.10). The CK showed a P × L interaction with quadratic effect (P = 0.02) and linear effect inside IDP program (P = 0.02). As the met requirement could increase in sanitary challenge the protein C-reactive was analyzed, and concentration was not influenced (P > 0.05) by programs or by methionine levels. Current results showed no evidence that supports toxicity of increasing the methionine until a lysine ratio up to 30% in both feeding-programs.