The peripartal dairy cows undergoes a state of reduced liver function linked with increased inflammation and oxidative stress. Objectives were to evaluate hepatic mRNA expression and systemic biomarkers of inflammation and oxidative stress in cows receiving supplementation of inorganic (INO) or organic (AAC) trace minerals. Twenty multiparous cows were assigned in a randomized complete block design to a common prepartal (1.5 Mcal/kg DM, 15% CP) and postpartal (1.76 Mcal/kg DM, 18% CP) diet. Both diets were partially supplemented with an inorganic mineral mix of Zn, Mn, and Cu to supply 35, 45, and 6 ppm, respectively, of the total diet DM. Treatments included cows receiving an oral bolus containing a mix of INO (n = 11) or AAC (n = 9) Zn, Mn, Cu, and Co to achieve 75, 65, 11, and 1 ppm, respectively, in total diet DM. Organic trace minerals were supplied via AvailaZn, AvailaMn, AvailaCu, and CoPro (Zinpro Corp., Eden Prairie, MN). Liver biopsies were collected at d −30, −15, 10 and 30, and blood samples at d −30, −14, 3, 15, and 30 relative to parturition. Although AAC did not affect biomarkers of liver function, an interaction (diet × time; P < 0.05) for the concentration of albumin, glutamic-oxaloacetic transaminase (GOT), cholesterol (CHO) and γ-glutamyltransferase (GGT) was observed. The lower GGT at d 15 and 30, and GOT at d 15 in cows receiving AAC suggests a lower degree of liver cell damage. Furthermore, greater albumin concentration at d 15 and 30 (P < 0.05), and greater gene expression of albumin (ALB; P < 0.01) and interleukin 10 (IL10; P = 0.03) in cows given AAC suggest a less pronounced inflammatory status. An interaction (diet × time; P < 0.05) was observed for signal transducer and activator of transcription 3 (STAT3) and superoxide dismutase 2 (SOD2) because expression increased from d 10 to 30 in cows fed AAC compared with INO. Overall, these data provide some evidence that source of trace mineral during the peripartal period alters immunometabolism.