The aim of this study was to fit and validate models to predict the metabolizable energy (ME) of meat and bone meal (MBM) for pigs. Thirty-two barrows (26.75 ± 1.45 kg) were allotted in a randomized blocks design with 8 treatments (7 MBM that replaced 20% the basal diet) and 4 replicates, to determine the ME. All MBM samples were analyzed for dry matter (DM), crude protein (CP), ether extract (EE), gross energy (GE), crude fiber (CF), mineral matter (MM), calcium (Ca) and phosphorus (P). The multiple linear regression models were adjusted using GE, CP, EE, MM, Ca and P as regressors (DM basis) using the ordinary least square method. To validate prediction equations, a database was compiled containing 48 pairs of observed and predicted ME. The 48 observed ME values were compiled from the literature and classified according to the scientific origin, resulting in 15 Brazilian data and 33 from international literature. The validity was initially assessed by adjusting the linear regression of 1st degree of the observed ME in function of the estimated ME, using the ordinary least squares. This procedure was adopted for the databases from the Brazilian, international and mixed literature. The validation of the estimated equations, as predictors of the linear ratio of ME, was checked by fitting a linear model of 1st degree of the predicted values (y = b₀ + b₁x_i) of ME by the equations initially estimated in function of the observed values. The ME values of MBM ranged from 1645 to 2645 kcal/kg. The prediction equations ME₁ = −4233.58 +0.4134GE +72P +89.62MM −159.06Ca (R² = 0.90); ME₂ = 2087.49 +0.3446GE +31.82MM −189.18Ca (R² = 0.87); ME₃ = 2140.13 +0.3845GE −112.33Ca (R² = 0.86); ME₄ = −346.58 +0.656GE (R² = 0.80); and ME₅ = 3221.27 +178.96EE −76.55MM (R² = 0.82) were effective in predicting the ME of Brazilian MBM. However, there was no validation when using data obtained from international researches. In conclusion, the equations that efficiently estimates the ME of MBM for pigs in Brazilian conditions are ME₁ = −4233.58 +0.4134GE +72CP + 89.62MM –159.06Ca and ME₂ = 2087.49 +0.3446GE +31.82EE –189.18Ca.