Feed additives such as ionophores and antibiotics have been shown to decrease ruminal methanogenesis, but evidence as a long-term means of mitigation is lacking. In the present study, we proposed a rotation of feed additives as an alternative to reduce methane (CH4) production and to increase animal responses. Rumen-cannulated steers (n = 12) were fed a basal high forage diet at 2% of BW (DM) for 13 wk in a Calan gate facility for individual DMI measurement. Steers were randomly assigned to 1 of 6 treatments: (1) control (C) containing the basal forage diet and no additive, (2) bambermycin (B) = C + 20 mg B/hd/d, (3) monensin (M) = C + 200 mg M/hd/d, (4) B7M = rotating B and M treatments weekly, (5) B14M = rotating B and M treatments every 14 d, and (6) B21M = rotating B and M treatments every 21 d. Steers were blocked by weight in a RCB design with repeated measures each wk. Performance data and rumen fluid were collected weekly for in vitro analysis (n = 13) and results were interpreted on organic matter intake (OMI) basis. Treatments did not affect ADG. Potential activity of CH4 (PAM) was greatest for M-fed steers and least for B21M-fed steers (0.219 vs 0.172 mM/kg OMI, respectively; P < 0.05). Additionally, PAM of the B21M-fed steers was most consistent of all treatments. Total VFA concentration differed (P < 0.05), being greatest for M- and B14M-fed steers (3.46 and 3.47 mM/Kg OMI) and lowest for the B7M treatment (2.87 mM/Kg OMI), but were not different from other treatments. The PAM differed over time for all treatments decreasing toward wk 6 then increasing toward wk 12. Wk also affected total VFA peaking at wk 3 followed by a significant depression in wk 4 (4.02 vs 2.86 mM/Kg OMI; P < 0.05). There is an evidence to suggest that weekly rotation of B and M feed additives may not provide additional benefit at either the ruminal or environmental level when compared with continuous feeding of single feed additives. However, a 21-d rotation may combine desirable animal performance, decreased CH4 emissions, and provide a novel practical approach for industry feeding protocol.