Traditionally, replacing a portion of milk protein in calf milk replacer (CMR) with plant and animal proteins has lowered CMR cost, but reduced calf growth performance. Newer processing methods for wheat protein have improved digestibility and when combined with bovine plasma as a partial replacement for milk protein in a CMR resulted in similar performance of calves fed an all milk protein CMR. The objective of this study was to compare performance of calves fed either a CMR containing a blend (B-CMR) of milk proteins (9% units protein), hydrolyzed wheat gluten protein (5% units protein) and bovine plasma (8% units protein) or all milk protein CMR (AM-CMR). Fifty-two 2- to 5-d-old Holstein heifer calves were randomly assigned to one of 2 CMR treatments. The B-CMR and AM-CMR were similar (DM basis) in CP (23%) and crude fat (21%) and fed at 0.54 kg DM/d (13% solids) from study d 1 to 35. Both B-CMR and AM-CMR contained Bio-Mos, ClariFly and 1600 g/ton each of Neomycin sulfate and Oxytetracycline the first 14 d of CMR feeding. BovaTec replaced oxy/neo from 15 d until weaning (d 42). From 35 to 42 d of study, CMR was fed at 0.27 kg DM/d. All calves were fed a common 22% CP (DM basis) texturized calf starter from study d 1 to 56. Data were analyzed as a randomized complete block design using PROC MIXED (SAS). Total intake of CMR DM from 1 to 42 d was similar at 20.8 kg DM with no differences in DM intake by weeks. Total calf starter DM intake from study d 1 to 42 was not different (P > 0.05) at 27.6 kg for AM-CMR fed calves and 25.4 kg for B-CMR fed calves. Total 56 d calf starter intake was not different between treatments at 64.6 vs. 61.1 kg DM for AM-CMR and B-CMR fed calves. Average daily gain from 1 to 42 d of study tended (P = 0.08) to be slightly lower for calves on B-CMR (0.69 kg/d) than calves on AM-CMR (0.75 kg/d). There was no difference (P > 0.05) in daily gain from 1 to 56 d between B-CMR treatment calves (0.83 kg/d) and AM-CMR treatment calves (0.87 kg/d). Fecal scores (1 normal, 4 watery) were numerically lower (1.4 vs. 1.6) from d 1 to 14 and scour days were numerically lower (1.27 vs 1.88) from d 1 to 42 for B-CMR calves than AM-CMR calves, respectively.