Supplementation with Sucram (SUC, Pancosma, Geneva, Switzerland) increases intestinal expression of sodium-glucose co-transporter 1, glucose uptake, and mucosal growth in ruminants. This trial aimed to determine the productive implications of this response in dairy cows. Primi- and multiparous lactating Holstein dairy cows were housed together in a freestall pen and were milked using an automated milking system (AMS). For 8 weeks, SUC was blended with a carrier and was dispensed at the AMS for SUC cows (n = 91) at a rate of 2.72 kg/d (SUC dose: 2g/cow/d); control cows received no additive (n = 89). Individual cow milk production and composition, milking frequency, and BW were recorded daily. Average DMI of the pen was monitored daily and did not change throughout the study. A treatment by stage of lactation interaction was observed: in cows that were greater than 100 DIM, there was no effect of SUC on any variables measured (P > 0.20). In contrast in cows less than 100 DIM, SUC enhanced milk production (44.5 vs. 45.6 kg/d; P ≤ 0.10). Milk fat (1.62 vs. 1.71 kg/d) and protein (1.41 vs. 1.46 kg/d) yields were also improved with SUC (P < 0.02); therefore, energy-corrected milk production was greater for SUC cows (46.0 vs. 48.0 kg/d; P < 0.01). There was a parity by treatment interaction for BW such that primiparous cows maintained condition regardless of treatment (P > 0.50) whereas multiparous cows supplemented with SUC lost BW during the trial (P < 0.001). Interestingly, there was also a parity by treatment interaction for number of daily milkings, which was increased by SUC in primiparous animals only (P < 0.001). This indicates that the increase in milk yield in those animals may have been due to greater frequency of milk removal whereas in multiparous cows it was due to mobilization of body reserves. These findings reveal that in early to mid-lactation, supplementation with SUC improves milk production performance and optimizes nutrient partitioning.