The optimization of performance of naturally fed beef cattle and the replacement of monensin (MON) are concerns constantly looked after by producers. Many phytomolecules have been reported to influence production efficiency of dairy and beef animals. Objective was to assess the effect of a standardized protected blend of cinnamaldehyde, eugenol and capsicum oleoresin (XT, XTRACT Ruminant, code X60–7065, Pancosma) on performance of beef cattle in 2 distinct commercial contexts: on top of a blank diet or as a substitute to MON, by 2 multiple trial analyses. A first set of data regrouped 10 trials organized in 7 studies (1290 growing cattle; mean initial BW of 276 kg; mean duration of 88 d, mean XT dose of 1.1 g/hd/d). All trials reported side by side comparisons of an unsupplemented control void of ionophore to the inclusion of XT in beef cattle. A second set of data regrouped 4 trials organized in 4 studies, all reporting side-by-side comparisons of the use of MON vs. XT (1004 growing cattle; mean initial BW of 215 kg; mean duration of 85 d, mean XT dose of 950 mg/hd/d; mean MON dose of 265 mg/hd/d). Outcomes selected were DMI, ADG and feed to gain ration (F:G). For each set of data, data were analyzed using a mixed model with the TRIAL variable as a random effect and the TRT variable as a fixed effect. Mean values were calculated using the LSMEANS procedure of XLstat, weighting the data for the variance among trials. Results showed that when added on top to a blank diet, XT did not affect DMI of beef cattle (mean: 7.18 kg/hd/d, P = 1.0), but increased ADG by 108 g/hd/d (P < 0.05) and reduced F:G by 7.5% (P < 0.05). The second analysis showed that XT numerically increased ADG and DMI compared with MON by respectively 2.4 and 4.7% (P = 0.2) without altering F:G (mean 4.82 g/g, P = 0.7). These findings are in line with available data on MON, and suggest that the addition of XT on top of a basal diet improves performance of beef cattle and can be safely used to replace MON.