Minerals can be a costly addition to a livestock ration, and farmers may choose to reduce mineral supplementation to reduce feed costs. Ru-Mend is a product designed to enhance nutrient absorption in the ruminant. Previous research demonstrated animals fed Ru-Mend had improved rumen osmolality, mineral digestibility and blood glucose versus the control. We hypothesized Ru-Mend supplementation could be a cost-effective way to improve mineral uptake and prevent performance issues in ruminants fed inadequate mineral levels. The objective of this study was to observe the effect of Ru-Mend on nutrient digestibility in ruminants fed reduced levels of supplemental minerals. Sixty Katahdin wethers (average BW 13 ± 3 kg) approximately 55 d of age were split into groups and fed an ad libitum corn silage plus alfalfa haylage-based diet with Ru-Mend, and either adequate (FULL) or reduced (RED) minerals for 52 d. The total mixed rations (TMR) were analyzed and RED diet observed to be lower by 30% in Co, Cu, Mn and Zn, 15% in S, 10% in Ca and Mg, and 5% in P compared with the FULL diet. Diets were balanced for K, Na and Cl, but there was a 10% reduction in Na for the RED TMR. Lambs were penned in groups of 15 with 2 pens per TMR treatment. For determination of DMI, digestibility, and nutrient utilization, 9 animals from each treatment were placed in digestibility crates for 5 d sample collection of orts, fecal and urine. ADG was calculated for each animal from their initial and 44 d body weight (BW). Data were analyzed by ANOVA completely randomized design. Lambs fed FULL treatment had significantly higher DMI (427.49 vs. 332.68 g/d; P < 0.0001) and ADG (102.15 vs. 72.17 g/d; P = 0.003) compared with RED. Also, FULL TMR-fed lambs had significantly higher digestibility of ADF, CP and NDF (P ≤ 0.03) and numerically higher DMD (P = 0.14). In addition, FULL lambs had significantly improved digestibility of Ca, Cu, Fe, K and S (P < 0.04) compared with RED. The data suggests lambs did not adequately benefit from Ru-Mend in the analyzed nutrient digestibility parameters or BW gain when the diet’s mineral level was insufficient, as in the RED diet.