Anaerobic storage of blends containing sorghum wet distillers grains plus solubles (WDGS) and low-quality roughages with or without microbial inoculants (DeLaval Manufacturing) on fermentation, losses, and aerobic stability were evaluated. Experimental silos (n = 90; 18.9-L plastic containers) were assigned randomly to 1 of the 15 treatments using a 3 × 3 + 6 treatment arrangement as follows: 65:35 blend of WDGS and one of the following roughage sources: wheat straw (WS), corn stalks (CS), and alfalfa hay:cottonseed hull (CSH) blend, with or without inoculant (n = 5; inoculant A and B, all roughages; C, D, and E only for CSH); roughages with no inoculants (cotton burrs (CB), and corn dry DGS:WDGS blend (52:48; DGS-blend); and pure WDGS. Data were analyzed using GLIMMIX procedures of SAS with d 0 as a covariate. Regardless of inoculation, pure WDGS showed greater (P < 0.01) total DM losses (8 vs. 2%), and less acetate (0.44 vs. 0.80%, DM basis) than silage blends. Low acetate concentration (0.13% of DM) was observed on d 0, regardless of treatment. Disappearance of fiber fractions was greater (P < 0.01) for blends than for pure WDGS. Inoculation tended (P = 0.07) to increase ADF digestibility for the CSH blend, and increased (P < 0.01) fiber disappearance for WS blends. Greater (P < 0.01) disappearance of NDF and ADF was observed for the WS blend plus inoculants A or B than for the average of other roughage treatments (16.80 vs. 4.57%, and 12.27 vs. 0% for NDF and ADF, respectively). Blends of CSH and CS had less (P ≤ 0.04) fat loss when inoculant A or B was applied vs. those without inoculant. The CSH blends took more time (P = 0.04; 6 h) to lose aerobic stability than other treatments. Independent of inoculation, pH and losses increased (P < 0.01) during the aerobic stability for WS, but was less for CSH, with CS blends being intermediate. Inoculation positively affected fermentation profile of ensiled WDGS/low-quality roughage blends, although this depended on type of roughage. Silo post-opening management of blends must be considered once it can account as an important source of loss.