Automated feeder systems (AFS) are gaining popularity in the dairy industry. Considering that calves intermingle in this system, it is important to evaluate and understand the risk of diseases and their impact on calf weight. This study examined the effect of cumulative health events (HE), respiratory disease (BRD), fever (F), and diarrhea (D), on 1-wk post-weaning weight (FWT) in calves. Holstein heifers (n = 96) from a 2 × 2 factorial study were used for this trial. Factorials were direct-fed microbial (DFM) efficacy and 2 pasteurized milk feeding plans that offered 543 L over 53 feeder days (FD). Plan 1 offered (7L/d) and peaked at 28 FD (13L/d). Plan 2 offered (11L/d) and peaked at 21 FD (15L/d). Both plans weaned calves at 53 FD. Researchers conducted complete health exams twice weekly from birth until FWT. Calves were weighed at 3 ± 2 d (Mean ± SD) of age and at FWT 66 ± 3 d. The effect of HE on FWT was evaluated by PROC MIXED in SAS, controlling for initial weight, age, and milk plan with study month as a random effect. The HE of calves were categorized into a score of 0, 1, 2, or 3 based on number of HE for each of the following: F, BRD, and D. A score of 0 indicated no HE, a score of 1 was 2–3 HE, a score of 2 was 4–5 HE, and a score of 3 was 6+ HE. For F, D, and BRD 22%, 20.8%, 19.8% of calves had a score of 0, respectively. For F, 52.1%, 18.8%, and 7.2% were categorized as 1, 2, and 3, respectively. For D, 53.1%, 24.0%, and 2.1% of calves scored 1, 2 and 3, respectively. For BRD 41.7%, 29.1%, and 9.4% of calves scored 1, 2, and 3, respectively. Final post weaning weight was 93.6 ± 12.9 kg (LSM ± SEM). Initial weight and final age were significantly associated with FWT (P < 0.0001), (P < 0.0001), respectively. For every increase in D HE score, FWT were lowered by −1.54 ± 0.62 kg (P < 0.02). For every additional F HE, FWT was lowered −1.05 ± 0.50 kg (P < 0.04). Final weight was not influenced by BRD (P = 0.54). Results suggest that diarrhea and fever have a cumulative effect on growth in dairy calves reared in AFS.