The objective of this study was to evaluate biochemical parameters of newborn goats from does that were supplemented with Selenium and Vitamin E. Twenty 4 kids from Saanen does that were supplemented starting on the fourth month of pregnancy until birth. The animals received the treatments based on the dams treatments and were divided into 3 groups: Control milk (base diet with 50% forage and 50% concentrate); Se milk (2.5 mg of Se/kg Dm added to the diet) and Sev milk (2.5 mg of Se/kg DM and 1000 IU/day of vitamin E/kg DM). The kids started receiving ad libitum access to feed from 7 d postpartum. The experiment took 28 d. After birth blood samples were collected before ingesting of colostrum and 48 h, 7, 14, 21 and 28 d postpartum. Blood samples were analyzed for serum protein analysis, albumin, gamma-glutamyl transferase (GGT), total cholesterol, high density lipoproteins (HDL), low density lipoproteins (LDL), triglycerides, aspartate aminotransferase (AST), creatine phosphokinase (CK), glucose, lactate, urea, creatinine, β-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA) and total antioxidant status (TAS). The experimental design was a complete randomized design with repeated measures, with 8 replications. Data were analyzed by ANOVA and the means were compared by Tukey test (P ≤ 0.05). There was no significant effect of treatment (P > 0.05) for the parameters of GGT, LDL, triglycerides, CK, glucose, urea, creatinine, BHB, NEFA and TAS. For serum protein and albumin parameters the Sev treatment provided significant increase (P < 0.05) when compared with the other treatments. There was a significant effects for Sev treatment (P < 0.05) for lactate, total cholesterol, HDL and AST, showing, therefore, a better oxidant activity in the group treated with selenium and vitamin E.