The objective of this study was to quantify the effect of breed description on the sale price of beef calves marketed through video auctions while adjusting for all other factors that significantly influenced price. Information on descriptive characteristics of lots of beef calves were obtained from a livestock video auction service. Data were available on 33,811 lots of calves (3,345,826 total calves) that sold in 116 video auctions between 2010 and 2014. All lot characteristics that could be accurately quantified or categorized were used to develop a multiple regression model that evaluated the effects of independent factors on sale price using a backward selection procedure. A value of P < 0.05 was used to maintain a factor in the final model. Breed description of the calves in the lot was 1 of 18 factors included in the original model and was categorized into 5 groups: English, English crosses (EX), English-Continental crosses (ECX), Black Angus sired out of dams with no Brahman influence (AN), Red Angus sired out of dams with no Brahman influence (AR), and Brahman influenced (BR). Breed of the lot affected the sale price of beef calves (P < 0.0001), and was 1 of 15 independent factors that remained in the final model. The number of lots in each breed group was 3,521, 9,022, 10,744, 1,373, and 9,151 for the EX, ECX, AN, AR, and BR breed groups, respectively. Lots of AR calves sold for a higher price (P < 0.01, $366.32/100 kg) than all other breed groups. Black Angus sired calves had the second highest sale price at $362.09/100 kg, and this price was higher (P < 0.01) compared with the EX ($359.04/100 kg), the ECX ($358.36/100 kg), and the BR ($350.05/100 kg) groups. The EX and the ECX breed groups sold for similar prices (P = 0.55), but both of these breed groups sold for higher prices (P < 0.01) than the BR lots. Breed composition of lots of beef calves selling through video auctions significantly influenced sale price.