Abstract #800

# 800
Roles for insulin-supported skeletal muscle growth.
Robert P. Rhoads*1, Lance H. Baumgard2, 1Virginia Tech, Blacksburg, VA, 2Iowa State University, Ames, IA.

Basic principles governing skeletal muscle growth and development, from a cellular point of view, have been realized for several decades. Skeletal muscle is marked by the capacity for rapid hypertrophy and increases in protein content. Ultimately, skeletal muscle growth is controlled by 2 basic means; myonuclear accumulation stemming from myoblast proliferation and the protein synthesis and degradation balance. Each process underlies the rapid changes in lean tissue accretion evident during fetal and neonatal growth and are particularly sensitive to nutritional manipulation. Although multiple signals converge to alter skeletal muscle mass, postprandial changes in the anabolic hormone, insulin, link feed intake with enhanced rates of protein synthesis in the neonate. Indeed, a consequence of insulin-deficient states such as diabetes or malnutrition is reduced myoblast activity and a net loss of body protein. A well-characterized mechanism mediating the anabolic effect of insulin involves the phosphatidylinositol 3-kinase (PI3K) mammalian target of rapamycin (mTOR) signaling pathway. Activation of mTOR leads to translation initiation control via the phosphorylation of downstream targets. Modulation of this pathway by insulin, as well as other hormones and nutrients, accounts for enhanced protein synthesis leading to efficient lean tissue accretion and rapid skeletal muscle gain in the growing animal. Dysfunctional insulin activity during fetal and neonatal life stages likely alters growth through cellular and protein synthetic capacities.

Key Words: insulin, skeletal muscle, myoblast

Speaker Bio
Dr. Robert P. Rhoads obtained his BS (96), MS (99), and PhD (04) from the Department of Animal Science at Cornell University. In 2004 Rob joined the University of Arizona in a NIH funded postdoctoral position. In 2006, Dr. Rhoads joined the faculty in the Department of Animal Sciences at the University of Arizona. In 2011, Rob joined the Animal and Poultry Sciences Faculty at Virginia Tech.  Current research interests focus on mammalian growth and development with an emphasis on the investigation of cellular and molecular mechanisms governing skeletal muscle growth and physiology.