Market availability and price of some conventional feedstuffs, such as corn, wheat, and soybean meal, are highly variable because of high demand for food, feed and fuel. Exploring alternative feedstuffs that can either completely or partially replace these feedstuffs is very important to ensure the sustainability of the swine industry. Use of these alternative feedstuffs in pig diets can be optimized by characterizing their nutrient profile and digestibility. To explore the nutritional value, 3 agro-industrial coproducts, barley brewers grain (BBG), okara and wheat millrun (WMR) were analyzed for basic nutrients, fiber and GE content. Digestibility of DM and GE was determined using an in vitro 3-step enzymatic assay using pepsin, pancreatin and viscozyme (which mimics the digestion occurring in the gastrointestinal tract of swine) with 4 replicates of each sample digested over 2 batches. All replicates were used to determine DM digestibility while 2 replicates from each batch of each feedstuff were used to determine GE digestibility. On a DM basis, nutrient profile were as follows. GE: 4073 (BBG), 4736 (WMR) and 4824 kcal/kg (okara); CP: 11.7 (BBG), 15.9 (WMR) and 22.7% (okara); NDF: 31.0 (okara), 35.0 and 42.0% (BBG); ADF: 19.7 (okara), 24.2 and 34.0% (BBG), and hemicellulose: 8.0 (BBG), 10.8 and 11.2% (okara). The DM digestibility of okara (74.1%) was higher (P < 0.05) than BBG (61.3%), WMR was in between (69.9%). Similarly, GE digestibility of okara (66.2%) was higher (P < 0.05) than BBG (43.0%), WMR was in between (53.1%). Okara is not merely a good source of protein and energy, but also had fairly high in vitro DM and GE digestibility in swine. In conclusion, some agro-industrial coproducts can be potential substitute for common ingredients used as energy sources in pig diets, especially for small farms where these coproducts are widely available.