Abstract #669

# 669
Browning of adipose tissue.
Shihuan Kuang*1, Pengpeng Bi1, Tizhong Shan1, 1Department of Animal Sciences, Purdue University, West Lafayette, IN.

Adipose (fat) tissues mediate systemic energy homeostasis, and play an important role in animal growth, health and reproduction. In addition, adipose tissues contribute to meat marbling and are thus a key determinant of meat quality. Fat cells within adipose tissues can be classified into white, beige and brown adipocytes mainly based on their mitochondria content. White adipocytes contain few mitochondria and are the predominant cell type in various subcutaneous and visceral fat depots. Brown adipocytes contain numerous mitochondria and are mainly found in interscapular brown adipose tissues of many mammals. Beige adipocytes are a newly defined type of adipocytes containing intermediate abundance of mitochondria and are found to coexist with white adipocytes in subcutaneous fat depots. While white adipocytes are primarily involved in energy storage (storing lipids), brown and beige adipocytes are highly specialized in energy expenditure due to their higher mitochondria content and abundant expression of uncoupling protein 1 (UCP1), which detours mitochondrial proton gradient from regular ATP production to instead generate heat to warm up the body. Recent studies indicate that white and beige adipocytes are interconvertible, and the conversion of white to beige adipocytes is called browning. In this talk, I will present our latest results on the molecular regulation of adipose browning and its implication in animal health, production and meat quality.

Key Words: white adipose tissue, brown adipose tissue, beige adipocyte

Speaker Bio
Dr. Shihuan Kuang received his Ph. D. from University of Alberta in 2002 and was then trained as a postdoctoral fellow at Washington University School of Medicine and Ottawa Hospital Research Institute. He became a faculty of Animal Sciences, Purdue University in 2008 and was promoted to tenured associate professor in 2013. Dr. Kuang is currently a faculty member of Purdue University Center for Drug Discovery and Center for Cancer Research. He is also a visiting professor of Chinese Academy of Medical Sciences. Dr. Kuang’s basic research in adult stem cells and muscle-fat interaction translate to applications in both animal agriculture and human health. Dr. Kuang has published over 70 refereed journal papers and book chapters, served on the editorial board or as a referee for many journals and grant panels. His research has been supported by National Institutes of Health, American Cancer Society, Muscular Dystrophy Association and United States Department of Agriculture.