Behavioral problems are the primary reason owners relinquish dogs to animal shelters. Interomones are olfactory cues produced by one species that elicit a response in another species. The objective of this study is to determine the effects of androstenone acting as an interomone to reduce leash-pulling behavior using a model of dog walking. Androstenone is a swine sex pheromone capable of eliminating jumping and barking in dogs; as such, it may also reduce leash pulling. This study took place at a local animal shelter using adoption dogs surrendered by owners due to behavioral issues, providing an exceptional model for this study. A researcher walked each dog on a standard nylon neck collar and leash 53 m around an enclosed yard (average time 76.0 ± 11.6 s). Leash pulling was defined as pressure exerted on the leash by the dog resulting in the researcher’s inability to walk comfortably. Each dog was walked twice with 90 min of rest between walks. On the first walk the researcher did not respond to leash pulling (NOT). On the second walk the researcher responded to each leash pull by spraying the designated treatment 46 cm from the dog’s head. Treatments were water (H₂O, n = 8), androstenone+water (ANH, n = 9), or InteroSTOP (Meridian Animal Health, Omaha, NE) (INT, n = 10). The study was designed so each dog was walked twice: once with NOT, and once with H2O, ANH or INT. Walks were video recorded and observed by researchers blind to the treatments. The observers counted number of leash pulls during each walk and noted reactions to sprays. Data were analyzed using a 2-tailed Student’s t-test, with number of leash pulls during the walk with NOT as the control for each treatment. ANH and INT reduced the number of leash pulls by 84% and 86%, respectively, compared with H₂O (P < 0.001). There was no difference in reduction of leash pulling between ANH and INT (P > 0.05). INT reduced leash pulling; however, the compressed air sound accompanying the spray frightened many dogs when sprayed from behind. These findings may be beneficial in developing behavioral modification training tools for dogs, thereby improving the human-animal bond and possibly reducing the desire of owners to relinquish ownership of dogs.