Sodium alendronate (SA) is a drug that shows effects on bone mass, which may contribute to better bone development of animals, allowing for more efficient production performance. This study was conducted to evaluate the influence of SA on performance and bone mineral density of Cobb broilers at 42 d of age. Twelve hundred broilers used in this study were derived from 2 treatments that included injection or no vitamin D injection during incubation. After the eggs hatched, the broilers received water containing different levels of sodium alendronate (0, 2, 4, 6 or 12 mg/mL). The water solution with SA was supplied through esophageal inoculation in broilers chicken once a week for 3 weeks. One milliliter of solution was given to each bird on 7, 14 and 35 d of age, to ensure that all animals ingested the treatment. Experimental design was completely randomized in a 2 × 5 factorial for a total of 10 treatments (injected or not × sodium alendronate level). Broiler performance was evaluated by calculating feed intake, body weight gain and feed conversion. Bone density of the tibiotarsus was analyzed at 42 d using DEXA equipment. Data were analyzed using the JMP program for ANOVA. For the performance parameters of the broilers there was no significant effect (P > 0.05), as well as for the densitometry results, though one can observe an increased bone density value (0.242 g/cm2) in broilers derived from eggs injected with vitamin D and subsequently treated with 4mg of SA level. Treatments with SA can increase total skeletal mass, but the data suggest that despite the non-significant results of SA in this experiment, a numerical increase in bone density was observed, hence an improvement in bone development. It was concluded there was no influence on broiler performance (P = 0.798) and for bone mineral density the level of 4 mg of SA was numerically (P = 0.246) better when compared with other treatments, which encourages us to continue our research to establish a significant level of SA. SA may enable us to increase bone mineral density, and possibly contribute to weight gain of broilers.