Montbéliarde × Holstein crossbred cows (MH, n = 484) and Viking Red × Holstein crossbred cows (VH, n = 510) were compared with pure Holstein cows (HO, n = 887) for 305-d milk, fat, and protein production and somatic cell score (SCS) during first lactation. A designed crossbreeding study was initiated in 8 commercial dairy herds in Minnesota in 2008. The first generation cows (MH, VH, and HO) calved for the first time from December 2010 to November 2013. Best Prediction was used to calculate production and SCS for 305-d lactations with adjustment for age at calving, and records less than 305 d were projected to 305 d. Independent variables for statistical analysis of all traits included the fixed effects of herd-year-season of calving, breed, interaction of herd-year-season and breed group, and random sire effect nested within breed. The MH, VH, and HO did not differ significantly for age at first calving (23.8 mo, 23.7 mo, and 23.8 mo, respectively). The MH and HO did not differ significantly (P = 0.81) for milk volume (11,304 kg vs. 11,272 kg, respectively); however, VH had significantly less (P < 0.01) milk volume (−495 kg) than HO. Fat solids production was similar (P > 0.17) for MH (429 kg) and VH (423 kg) compared with HO (423 kg). However, the MH had significantly greater (P < 0.01) protein production (355 kg vs. 344 kg) and fat plus protein production (784 kg vs. 767 kg) compared with HO. The protein production and fat plus protein production of VH (344 kg and 767 kg, respectively) were similar (P > 0.94) to pure HO. The MH (2.2), and VH (2.2) were also similar (P > 0.27) to HO (2.1) for SCS. The results have potential effect on the calculation of lifetime profit of cows because revenue from milk solids is the largest component of total revenue in many regions of the world.