There is an increased interest in screening phytogenic extracts and medicinal plants as alternatives to the traditional drugs. The efficacy of Salix babylonica (SB) extract as a alternative control of gastrointestinal and pulmonary parasites in sheep and goats at the commercial scale was tested. A sample of 20% of the population of 8 sheep and 7 goat farms was included. About 20 mL of SB extract was orally administered weekly at 0700–0900 h before morning feeding for 60 d. A fecal egg or oocyst count technique was performed after 0 (pre-extract administration), 1, 20, 40 and 60 d after the extract administration. Fecal samples were evaluated for the presence of coccidian oocysts, cestode and nematode eggs by a salt flotation technique. Afterward, oocysts or eggs were counted using the McMaster method. Significantly differences (P < 0.01) in the fecal oocyst and egg output of Eimeria, Dictyocaulus, and Moniezia were observed between sheep and goats. The treatment influenced (P < 0.05) egg outputs of Cooperia, Dictyocaulus and Trichuris. The fecal egg or oocyst counts of Haemonchus contortus, Eimeria, Cooperia, Chabertia, Dictyocaulus, Moniezia and Ostertagia were time-dependent (P < 0.05). For sheep, administration of SB decreased (P < 0.05) the fecal eggs count of H. contortus, Cooperia, Chabertia, Dictyocaulus, Moniezia and Trichuris. After 20 d of treatment, no H. contortus, Cooperia or Moniezia were detected. For goats, only a few species were affected (P < 0.05) after the SB administration. The SB reduced (P < 0.05) the fecal eggs count of H. contortus, Cooperia, Chabertia and Moniezia. Quadratic decreases were observed (P < 0.05) for Chabertia, Trichostrongylus and Ostertagia. Eggs of H. contortus and Moniezia were not present in the feces of goats after one day of treatment; in contrast to the egg output of Trichostrongylus and Ostertagia. It is therefore concluded that weekly administration of SB at 20 mL weekly can be a promising alternative to the use of synthetic anthelmintics to treat gastrointestinal and lung nematodes of small ruminants in organic and conventional production systems.