One hundred forty weaning pigs [(Yorkshire × Landrace) × Duroc] with an average BW of 5.70 ± 1.41 kg (21 d) were used in a 6-wk experiment to evaluate the effect of extracted rice bran (ERB) on growth performance, ATTD of nutrients, diarrhea score, blood profiles, fecal microbial shedding and fecal noxious gas emissions. Weaning pigs were allotted to diets containing 0 or 0.1 g ERB/kg of diet and 2 levels of antibiotic (tiamulin; ANT, 0 and 33 ppm) according to a 2 × 2 factorial arrangement of treatments. There were 7 replicated pens per treatment with 5 pigs per pen. The experiment included 2 phases: 0 to 2 weeks and 2 to 6 weeks. At 2 and 6 wk, 2 pigs from each pen were subjected for the fecal microbiota and blood profiles. All data were statistically analyzed using the repeated-measure statement of the MIXED procedure of SAS. The model included diet as a fixed effect whereas pig and period were included as random effects. During phase 1 and overall, ERB supplementation increased growth efficiency (G:F) compared with the ERB-free diet in weaning pigs (0.84 vs. 0.80 and 0.69 vs. 0.67; P = 0.01 and P = 0.04, respectively). Pigs receiving diets supplemented with ANT increased DM and N digestibility than their counterparts during phase 1 (82.89 vs. 81.19% and 82.85 vs. 80.71%; P = 0.04 and 0.01, respectively). Pigs fed ERB had higher N digestibility than pigs fed the non-ERB diet during phase 1 and phase 2 (83.60 vs. 79.96% and 82.48 vs. 79.22%, P = 0.01 and 0.02, respectively). Supplementation of ANT × ERB diets had positive effects for DM digestibility (P = 0.04). During phase 2, the supplementation of ERB decreased total cholesterol (TC) than pigs fed the diet lacking ERB (97.30 vs. 103.60 mg/dL; P = 0.01). During phase 2, the supplementation of ERB increased the Lactobacillus and reduced Salmonella counts than pigs fed the ERB-free diet (7.72 vs. 7.58 log₁₀ cfu/g and 2.37 vs. 2.49 log₁₀ cfu/g; P = 0.04 and P = 0.02, respectively). Pigs fed ERB diets reduced ammonia (NH₃) gas emission compared with non-ERB diets (22.70 vs. 26.46 ppm; P = 0.01). In conclusion, results indicated that dietary supplementation of ERB improved performance in weaning pigs.