A total of 120 weaning pigs [(Landrace × Yorkshire) × Duroc; BW = 8.95 ± 0.88 kg] were allotted to 4 treatments (6 pens/treatment, 5 pigs/pen) to evaluate the effect of anise flavor (F), sweetener (ST), and compound of them in weaning pigs. Treatments were as follows: 1) control, 2) control + 500 ppm F, 3) control + 150 ppm ST, 4) control + 500 ppm F + 150 ppm ST. Individual pig BW and pen feed intake were recorded on d 1, 14 and 42 (phase 1: d 1–14, phase 2: d 15–42) to calculate ADG, ADFI, and G:F. Cr₂O₃ (0.2%) was added to the diets from d 7 to 14 and d 35 to 42 as indigestible marker to determine apparent total-tract digestibility (ATTD) of DM, N, and GE. Blood samples were collected from the cervical vein of 2 pigs in each pen at 24, 48, and 72 h after weaning. Subjective diarrhea scores were recorded daily from d 1 to 7 and d 8 to 14. Data were analyzed as 2 × 2 factorial arrangement by using the GLM Procedure of SAS. During d 1 to 14, ADFI (-F vs. +F = 412 vs. 447.5 g; -ST vs. +ST = 407.5 vs. 452 g) and ADG (-F vs. +F = 323 vs. 355 g; -ST vs. +ST = 317.5 vs. 360.5 g) respectively improved by F (P < 0.01) and ST (P < 0.01) supplementation. During d 1 to 42, ST increased ADFI (-ST vs. +ST = 689.5 vs. 732 g; P < 0.01) and ADG (-ST vs. +ST = 461 vs. 508 g; P < 0.05). Digestibility of N was improved (-ST vs. +ST = 83.5 vs. 86.1%; P < 0.05) in ST treatments on d 14. The epinephrine level at 48 h after weaning was decreased (-ST vs. +ST = 154 vs. 148.5 pg/mL; P < 0.05) by supplementation of ST. Diarrhea score (scoring system from 1 to 5) was decreased (P < 0.05) by F (-F vs. +F = 4.04 vs. 3.93) and ST (-ST vs. +ST = 4.05 vs. 3.92) during d 1 to 7. No interaction effect was observed in our experiment. In conclusion, sweetener improved growth performance and nutrient digestibility, decreased serum norepinephrine concentration, epinephrine concentration and diarrhea score. Anise flavor could improve growth performance, decreased norepinephrine concentration and diarrhea score after weaning. It implies the benefit of anise flavor and sweetener might be more effective in the first week after weaning, and the effect sweetener seems better than anise flavor.